Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schwinger, W; Mache, C; Urban, C; Beaufort, F; Töglhofer, W.
Single dose of filgrastim (rhG-CSF) increases the number of hematopoietic progenitors in the peripheral blood of adult volunteers.
Bone Marrow Transplant. 1993; 11(6):489-492
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- Führende Autor*innen der Med Uni Graz
- Schwinger Wolfgang
- Co-Autor*innen der Med Uni Graz
- Mache Christoph
- Urban Ernst-Christian
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- Abstract:
- Hematopoietic progenitor cell levels were monitored in the peripheral blood of ten healthy adults receiving a single dose of recombinant human granulocyte colony-stimulating factor (rhG-CSF). The objective was to determine the time and number of progenitor cells released into the peripheral blood, induced by a single dose of 15 micrograms/kg rhG-CSF administered intravenously. In all cases the absolute number of circulating progenitor cells including granulocyte-macrophage and erythroid lineages increased up to 12-fold (median 9.4-fold) 4 days after treatment. These findings were based on flow cytometric quantification of CD34+ cells and on progenitor assays. The relative distribution of granulocyte/macrophage and erythroid progenitors remained unchanged. rhG-CSF was well tolerated; mild to moderate bone pain was the most common side-effect and was noted in 6 of 10 subjects. Thus a single dose of rhG-CSF is effective in mobilizing progenitor cells into the peripheral blood in healthy adults. If these progenitors are capable of reconstituting bone marrow, peripheral progenitor cell separation following rhG-CSF administration could be a reasonable alternative to conventional bone marrow harvest in healthy adults.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Colony-Stimulating Factors - pharmacology
- Female - pharmacology
- Filgrastim - pharmacology
- Hematopoietic Stem Cells - cytology
- Humans - cytology
- Leukocyte Count - cytology
- Male - cytology
- Recombinant Proteins - pharmacology