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Selected Publication:
Weiss, PA; Kainer, F; Pürstner, P; Zehetleitner, G; Hüttner, U; Haas, J.
Anti-insulin antibodies and birth weight in pregnancies complicated by diabetes.
Early Hum Dev. 1998; 53(2):145-154
Doi: 10.1016%2FS0378-3782%2898%2900047-4
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- Co-authors Med Uni Graz
- Haas Josef
- Pürstner Peter
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- Abstract:
- Free insulin cannot cross the placenta but insulin complexed to anti-insulin antibodies has been demonstrated in cord blood. We studied whether antibody-bound insulin in diabetic patients can evoke fetal macrosomia independently of maternal metabolic control. In 457 non insulin-treated controls and 173 insulin-treated diabetic patients we measured 1187 anti-insulin antibody levels and maternal blood glucose, maternal fructosamine, cord blood insulin, cord blood C-peptide, cord blood fructosamine and amniotic fluid insulin. Mean anti-insulin antibody levels in maternal blood and cord blood were significantly higher in insulin treated diabetic patients (4.6 and 5.4 U/ml) than in controls (1.8 and 1.7 U/ml) with maxima of 89.2 in maternal and 120.0 U/ml in cord blood, respectively. In insulin treated diabetic patients 16.6% (maternal blood) and 22% (cord blood) anti-insulin antibody levels were above the 97th percentile. There was a high significant correlation between maternal and cord blood anti-insulin antibodies (R = 0.987, P = < 0.0001), but no correlation of anti-insulin antibodies with maternal (glucose, fructosamine) or fetal (insulin, C-peptide, and fructosamine in cord blood, amniotic fluid insulin) metabolic parameters. While maternal and fetal metabolic parameters correlated with birth weight neither maternal nor cord blood anti-insulin antibody levels correlated with birth weight. These findings do not support the hypothesis that maternal anti-insulin antibodies independently influence fetal weight.
- Find related publications in this database (using NLM MeSH Indexing)
- Amniotic Fluid - chemistry
- Autoantibodies - blood
- Birth Weight -
- Blood Glucose - analysis
- C-Peptide - blood
- Diabetes Mellitus, Type 1 - immunology
- Diabetes, Gestational - immunology
- Female -
- Fetal Blood - chemistry
- Fructosamine - blood
- Humans -
- Infant, Newborn -
- Insulin - analysis Insulin - blood Insulin - immunology
- Pregnancy -
- Pregnancy in Diabetics - immunology
- Find related publications in this database (Keywords)
- Maternal Antiinsulin Antibodies
- Antiinsulin Antibodies in Cord Blood
- Birth-Weight
- Gdm
- IDDM