Medizinische Universität Graz - Research portal
Selected Publication:
Pöch, G; Vychodil-Kahr, S; Petru, E.
Sigmoid model versus median-effect analysis for obtaining dose-response curves for in vitro chemosensitivity testing.
Int J Clin Pharmacol Ther. 1999; 37(4):189-192
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Petru Edgar
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- Abstract:
- AIM: The aim of this study was to determine how the in vitro dose-response effects of chemotherapeutic agents should be analyzed and reported. METHODS: We arbitrarily evaluated the effects of mitomycin-C and 4-OH-cyclophosphamide on the human ovarian cancer cell line CAOV-3. Dose-response curves (DRCs) were calculated by non-linear (sigmoid model: SigmaPlot) and linear curve fitting (median-effect analysis: CalcuSyn). RESULTS: In theory and practice, the sigmoid model provided better curve fits and graphical presentation than the median-effect analysis. CONCLUSION: Thus, this model should preferably be used as a basis for selection of anti-cancer drugs for clinical use.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibiotics, Antineoplastic - administration and dosage
- Cyclophosphamide - administration and dosage
- Dose-Response Relationship, Drug - administration and dosage
- Female - administration and dosage
- Humans - administration and dosage
- Linear Models - administration and dosage
- Mitomycin - administration and dosage
- Models, Statistical - administration and dosage
- Ovarian Neoplasms - drug therapy
- Tumor Cells, Cultured - drug therapy
- Find related publications in this database (Keywords)
- Mitomycin-C
- 4-Oh-Cyclophosphamide
- Curve Fitting Comparison
- Sigmoid Model
- Median-Effect Model
- Graphical Presentation