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Selected Publication:
Winklhofer-Roob, BM; Shmerling, DH; Schimek, MG; Tuchschmid, PE.
Short-term changes in erythrocyte alpha-tocopherol content of vitamin E-deficient patients with cystic fibrosis.
AMER J CLIN NUTR. 1992; 55(1): 100-103.
Doi: 10.1093/ajcn/55.1.100
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- Co-authors Med Uni Graz
- Schimek Michael
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- Abstract:
- Polyunsaturated fatty acids of biomembranes are a major target of lipid peroxidation. In vitamin E deficiency an efficient delivery of a high oral loading dose of all-rac-alpha-tocopheryl acetate to erythrocyte membranes could provide an early onset antioxidative effect. We investigated short-term changes in erythrocyte alpha-tocopherol after a single oral dose of 100 mg all-rac-alpha-tocopheryl acetate/kg in 10 vitamin E-deficient cystic fibrosis (CF) patients. Over 24 h, erythrocyte alpha-tocopherol increased 68% to 420% of preloading concentrations. With two exceptions, peak values were achieved 12 or 24 h after administration, which was 3-18 h later than peak plasma concentrations. Separate median-based curve estimates for the changes in erythrocyte alpha-tocopherol for five patients with and five without associated cholestatic liver disease were obtained. Cross-sectional test results revealed significantly lower erythrocyte alpha-tocopherol for the 9- and 24-h observations for patients with cholestatic liver disease compared with those without. Oral all-rac-alpha-tocopheryl acetate can be rapidly incorporated into erythrocyte membranes in vitamin E-deficient CF patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Child -
- Child, Preschool -
- Cholestasis, Intrahepatic - blood
- Cross-Sectional Studies - blood
- Cystic Fibrosis - blood
- Erythrocytes - chemistry
- Follow-Up Studies - chemistry
- Humans - chemistry
- Infant - chemistry
- Random Allocation - chemistry
- Vitamin E - blood
- Vitamin E Deficiency - blood
- Find related publications in this database (Keywords)
- Erythrocyte Alpha-Tocopherol
- Vitamin-E Deficiency
- Cystic Fibrosis
- Cholestatic Liver Disease