Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Beubler, E; Schirgi-Degen, A.
Serotonin antagonists inhibit sennoside-induced fluid secretion and diarrhea.
Pharmacology. 1993; 47 Suppl 1(2):64-69
Doi: 10.1159/000139844
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Beubler Eckhard
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- Abstract:
- The aim of this study was to investigate whether 5-hydroxytryptamine (serotonin, 5-HT) is involved in the mediation of sennoside-induced colonic fluid secretion and diarrhea. Oral administration of purified sennosides (25, 40 and 64 mg/kg) dose-dependently reversed net fluid absorption to net fluid secretion, enhanced the incidence of diarrhea and stimulated the release of 5-HT into the colonic lumen from 7.1 to 17.3 ng/g wet weight. The 5-HT2 antagonist ketanserin and the 5-HT3 antagonist tropisetron dose-dependently but only partially reduced sennoside (40 mg/kg)-induced fluid secretion whereas the 5-HT3 antagonist granisetron dose-dependently reduced and at 300 micrograms/kg totally abolished sennoside-induced secretion. Granisetron, but not ketanserin and tropisetron, reduced the incidence of diarrhea in sennoside-treated rats, indicating the involvement of 5-HT also in acceleration of large intestinal transit. It is concluded that 5-HT is an important mediator both of sennoside-induced fluid secretion in the rat colon and of diarrhea.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anthraquinones - antagonists and inhibitors
- Colon - drug effects
- Diarrhea - metabolism
- Dose-Response Relationship, Drug - metabolism
- Female - metabolism
- Intestinal Absorption - metabolism
- Intestinal Secretions - drug effects
- Rats - drug effects
- Rats, Sprague-Dawley - drug effects
- Serotonin - physiology
- Serotonin Antagonists - pharmacology
- Water - metabolism
- Find related publications in this database (Keywords)
- Sennosides
- Intestinal Secretion
- Serotonin
- Ketanserin
- Tropisetron
- Granisetron