Medizinische Universität Graz - Research portal
Selected Publication:
Bauernhofer, T; Stöger, H; Schmid, M; Smola, M; Gürtl-Lackner, B; Höfler, G; Ranner, G; Reisinger, E; Samonigg, H.
Sequential treatment of recurrent mesenteric desmoid tumor.
Cancer. 1996; 77(6):1061-1065
Doi: 10.1002/(SICI)1097-0142(19960315)77:6<1061::AID-CNCR9>3.0.CO;2-K
(- Case Report)
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Bauernhofer Thomas
- Co-authors Med Uni Graz
- Gürtl-Lackner Barbara
- Höfler Gerald
- Samonigg Hellmut
- Smola Michael
- Stöger Herbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The optimal management of inoperable desmoid tumors is still unclear. We report a 26 year-old female patient with familial adenomatous polyposis suffering from a recurrent inoperable intraabdominal desmoid tumor and its sequential treatment. Treatment strategies included low-dose tamoxifen (30 mg orally per day), high-dose tamoxifen (90 mg orally per day), and a subsequent combination of goserelin acetate (3.6 mg subcutaneously once every four weeks) plus low-dose tamoxifen, medroxyprogesterone acetate (1000 mg orally per day) and interferon gamma (3 Mio IU subcutaneously 3 times a week). The combination of goserelin acetate and low-dose tamoxifen resulted in a decrease in tumour size and a complete relief of symptoms for 17 months. Thereafter the tumor progressed and again growth was stopped with interferon gamma therapy for another 6 months. All other treatment modalities had no effect. This study demonstrates long-term regression of a desmoid tumor with combined endocrine therapy using goserelin acetate plus tamoxifen. Tumor progression after 17 months was again stopped by a combination of interferon-gamma and goserelin acetate.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenomatous Polyposis Coli - pathology
- Adult -
- Antineoplastic Combined Chemotherapy Protocols - administration & dosage
- Drug Administration Schedule -
- Female -
- Fibromatosis, Aggressive - diagnostic imaging
- Fibromatosis, Aggressive - therapy
- Goserelin - administration & dosage
- Humans -
- Interferon-gamma - administration & dosage
- Medroxyprogesterone - administration & dosage
- Mesentery -
- Neoplasm Recurrence, Local -
- Neoplasms, Multiple Primary -
- Peritoneal Neoplasms - diagnostic imaging
- Peritoneal Neoplasms - therapy
- Tamoxifen - administration & dosage
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- Desmoids
- Familial Adenomatous Polyposis
- Goserelin Acetate
- Tamoxifen
- Medroxyprogesterone Acetate
- Interferon Gamma
- Adenomatous Polyposis Coli Gene