Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zoubek, A; Kovar, H; Kronberger, M; Amann, G; Windhager, R; Gruber, B; Gadner, H.
Mobilization of tumour cells during biopsy in an infant with Ewing sarcoma.
Eur J Pediatr. 1996; 155(5):373-376
Doi: 10.1007/BF01955264
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Windhager Reinhard
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- Abstract:
- Ewing sarcoma and the closely related peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene rearrangements on chromosome 22. The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS proto-oncogens, FLI-1 or ERG, which reside on chromosomes 11 and 21, respectively. The rearrangement results in the expression of specific hybrid transcripts which can be detected with high sensitivity by the reverse transcriptase polymerase chain reaction technique (RT-PCR) in primary tumours, blood and bone marrow. We report on a 7-month-old boy with a pelvic Ewing sarcoma in whom circulating tumour cells were identified in the peripheral blood during open tumour biopsy by RT-PCR. However, before and 6 days after surgery no tumour cells could be detected in the peripheral blood. CONCLUSION: The application of RT-PCR to monitor shedding of tumour cells during surgical intervention will help to evaluate if open biopsy potentially contributes to metastatic tumour cell spread.
- Find related publications in this database (using NLM MeSH Indexing)
- Base Sequence -
- Biopsy -
- Bone Neoplasms - blood
- Humans - blood
- Infant - blood
- Male - blood
- Molecular Sequence Data - blood
- Neoplasm Circulating Cells - blood
- Neoplasm Metastasis - blood
- Polymerase Chain Reaction - blood
- Sarcoma, Ewing's - blood
- Transcription, Genetic - blood
- Find related publications in this database (Keywords)
- Ewing tumours
- EWS-FLI-1 fusion transcripts
- circulating tumour cells
- tumour biopsy
- minimal metastatic disease