Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zoubek, A; Kajtar, P; Flucher-Wolfram, B; Holzinger, B; Mostbeck, G; Thun-Hohenstein, L; Fink, FM; Urban, C; Mutz, I; Schuler, D.
Response of untreated stage IV Wilms' tumor to single dose carboplatin assessed by up front window therapy.
Med Pediatr Oncol. 1995; 25(1):8-11
Doi: 10.1002/mpo.2950250103
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- Co-Autor*innen der Med Uni Graz
- Urban Ernst-Christian
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- Abstract:
- A total of nine children with previously untreated stage IV Wilms' tumor of favorable histology were treated according to the Austrian/Hungarian Wilms' Tumor Protocol 89 and received a preoperative single dose of carboplatin as an "up front" window therapy. The treatment consisted of carboplatin as a single-dose of 600 mg/m2 over 30 minutes on day 1. Response evaluation by chest X-ray, serial CT scans, and sonography was performed on day 22. Investigation of the abdominal tumors revealed seven partial responses (78%), one nonresponse, and one progressive disease with a median tumor volume reduction of 62%. Response of metastases evaluated by CT scans was as follows: four complete remission, four partial response, and one nonresponse. Thrombocytopenia (WHO grade III 1, grade II 2, grade I 2) and leukocytopenia (WHO grade II 1, grade I 5) were the main side effects. No renal or liver toxicity were observed. The overall response rate after a preoperative single-dose of 600 mg/m2 carboplatin in untreated patients with stage IV Wilms' tumor is encouraging and the toxicity acceptable. This data indicate that carboplatin seems to be an additional effective drug in patients with previously untreated Wilms' tumor of favorable histology.
- Find related publications in this database (using NLM MeSH Indexing)
- Austria -
- Carboplatin - administration and dosage
- Child - administration and dosage
- Child, Preschool - administration and dosage
- Female - administration and dosage
- Humans - administration and dosage
- Hungary - administration and dosage
- Infant - administration and dosage
- Kidney Neoplasms - drug therapy
- Liver Neoplasms - drug therapy
- Lung Neoplasms - drug therapy
- Male - drug therapy
- Neoplasm Staging - drug therapy
- Wilms Tumor - drug therapy
- Find related publications in this database (Keywords)
- Wilms Tumor Stage-IV
- Nephroblastoma
- Carboplatin (Cbdca)
- Preoperative Chemotherapy