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Petru, E; Pickel, H; Heydarfadai, M; Lahousen, M.
Remission induction with carboplatin-epirubicin-prednimustine followed by consolidation radiotherapy in advanced ovarian cancer.
INT J CLIN PHARM RES. 1992; 12(4): 205-207.
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Leading authors Med Uni Graz: Petru Edgar
Co-authors Med Uni Graz: Lahousen Manfred
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Abstract:: Adjuvant chemoradiotherapy was administered to 26 patients with stage Ic-IV ovarian cancer after radical cytoreductive surgery. All patients received six cycles of carboplatin, epirubicin, and prednimustine and had no clinical evidence of disease after completion of chemotherapy. They received whole-abdominal radiation and radiation to the retroperitoneal lymph nodes. This protocol was discontinued for five (23%) patients because of myelosuppression, progressive disease, or withdrawal. One patient had a small bowel obstruction due to intraperitoneal adhesions. The survival of ten stage-III ovarian cancer patients, who received chemoradiotherapy and were evaluable for assessment of treatment efficacy, was retrospectively compared with the survival of 11 stage-III patients who received chemotherapy only. At 36 months, a slight advantage of the chemoradiotherapy versus the chemotherapy-only group was observed (p = 0.11). These preliminary results suggest that adjuvant chemoradiotherapy may prolong the "no evidence of disease" interval of radically operated ovarian cancer patients. Toxicity is acceptable when second-look surgery is avoided and when subsequent radiotherapy is limited to patients with no evidence of disease.
Find related publications in this database (using NLM MeSH Indexing): Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carboplatin - administration and dosage; Chemotherapy, Adjuvant - administration and dosage; Combined Modality Therapy - administration and dosage; Epirubicin - administration and dosage; Female - administration and dosage; Humans - administration and dosage; Lymphatic Irradiation - administration and dosage; Ovarian Neoplasms - drug therapy; Prednimustine - administration and dosage; Remission Induction - administration and dosage