Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Sudi, KM; Gallistl, S; Weinhandl, G; Muntean, W; Borkenstein, MH.
Relationship between plasminogen activator inhibitor-1 antigen, leptin, and fat mass in obese children and adolescents.
Metabolism. 2000; 49(7):890-895
Doi: 10.1053/meta.2000.6736
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- Co-Autor*innen der Med Uni Graz
- Borkenstein Helmuth Martin
- Gallistl Siegfried
- Muntean Eugen
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- Abstract:
- Hyperleptinemia may be associated with cardiovascular risk and is linked with parameters of fibrinolytic processes in adults. We studied whether body fatness, leptin, and insulin interact with plasminogen activator inhibitor-1 antigen (PAI-1-Ag) and tissue-type plasminogen activator antigen (tPA-Ag) in obese children and adolescents. Twenty-three boys (mean +/- SD: age, 10.7 +/- 3.3 years; body mass index [BMI], 28.7 +/- 5.4 Kg/m2) and 19 girls (age, 11.9 +/- 2.7 years; BMI, 29.4 +/- 4.8 Kg/m2) were investigated. Body fat mass (FM) in the children was calculated by bioelectrical impedance analysis, and blood samples were obtained for leptin, insulin, C-peptide, PAI-1-Ag, and tPA-Ag. The children were divided into 3 subgroups according to maturation. Maturity was associated with greater adiposity and higher levels of leptin and C-peptide, but insulin and PAI-1-Ag were not different between prepubertal, pubertal, and late/postpubertal children. PAI-1-Ag was associated with leptin and insulin, but not after adjustment for fatness. PAI-1-Ag was independently associated with tPA-Ag (r = .36, P < .02). Multiple regression analysis showed that tPA-Ag failed to reach the level of significance (P = .07), but FM contributed to the variation in PAI-1-Ag (adjusted R2 = .29). The BMI was the main determinant for the variation in leptin (adjusted R2 = .386) and in insulin (adjusted R2 = .60, all P < .001). Neither gender, maturation, chronological age, or leptin contributed significantly to the variation in either PAI-1-Ag or tPA-Ag. Our data suggest that adiposity and other variables contribute to higher levels of PAI-1-Ag. Leptin seems not to be independently linked with fibrinolytic parameters, but an unfavorable metabolic and fibrinolytic risk profile might emanate from the obese pubertal stage.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - metabolism
- Adolescent - metabolism
- Body Mass Index - metabolism
- Child - metabolism
- Female - metabolism
- Fibrinolysis - metabolism
- Humans - metabolism
- Leptin - analysis
- Male - analysis
- Obesity - metabolism
- Plasminogen Activator Inhibitor 1 - blood
- Puberty - metabolism
- Regression Analysis - metabolism
- Sex Factors - metabolism