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Barthó, L; Kóczán, G; Holzer, P; Maggi, CA; Szolcsányi, J.
Antagonism of the effects of calcitonin gene-related peptide and of capsaicin on the guinea-pig isolated ileum by human alpha-calcitonin gene-related peptide(8-37).
Neurosci Lett. 1991; 129(1):156-159
Doi: 10.1016/0304-3940(91)90744-E
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- Co-authors Med Uni Graz
- Holzer Peter
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- Abstract:
- The possible mediating role of calcitonin gene-related peptide (CGRP) in the effects of capsaicin in the guinea-pig ileum has been investigated by means of the CGRP antagonist hCGRP(8-37). Submaximal longitudinal muscle relaxation of the histamine-precontracted ileum evoked by rat CGRP (3 nM) or capsaicin (1 microM) was reversed by hCGRP(8-37) (1.5 microM), while that due to adrenaline or neurotensin was not affected. Inhibition of spontaneous circular muscle movements by capsaicin (100 nM) was also reversed by hCGRP(8-37). The CGRP antagonist had no effect on electrical stimulation-evoked ileal contractions or on the longitudinal or circular muscle tone. It is concluded that (a) hCGRP(8-37) is a specific CGRP antagonist in the ileum, apparently devoid of intrinsic activity or any effect not related to CGRP; (b) the inhibitory actions of capsaicin on the longitudinal and circular muscles of the ileum are mediated, at least in part, by CGRP.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Atropine - pharmacology
- Calcitonin Gene-Related Peptide - antagonists & inhibitors
- Capsaicin - antagonists & inhibitors
- Guinea Pigs -
- Ileum - drug effects
- Male -
- Muscle Contraction - drug effects
- Peptide Fragments - pharmacology
- Find related publications in this database (Keywords)
- Enteric
- Capsaicin
- Calcitonin Gene-Related Peptide
- CGRP Antagonist