Medizinische Universität Graz - Research portal
Selected Publication:
Franke, U; Wahlers, T; Cohnert, TU; Koenig, J; Rath, NF; Wirsing, M; Haverich, A.
Retrograde versus antegrade crystalloid cardioplegia in coronary surgery: value of troponin-I measurement.
Ann Thorac Surg. 2001; 71(1):249-253
Doi: 10.1016/S0003-4975(00)02145-7
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Cohnert Tina Ulrike
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: The optimal route for delivery of cardioplegia is still in debate in patients with ischemic heart disease. Cardiac troponin-I is a new marker with the potential for detection of minor differences in myocardial ischemia. METHODS: In a prospective randomized trial 58 patients undergoing elective coronary artery bypass grafting for two- or three-vessel coronary artery disease were divided into groups with antegrade (group A, n = 29) and retrograde (group R, n = 29) application of crystalloid cardioplegia (St. Thomas II). Patients with major risk factors were excluded. In addition to routine electrocardiogram monitoring, cardiac troponin-I and creatine kinase-MB activity were measured in all patients preoperatively at 2, 5, 8, 24, and 48 hours after aortic cross-clamp release, and at hospital discharge. RESULTS: In both groups, there were no differences regarding operative parameters. A significantly higher cardiac troponin-I concentration was observed in the antegrade group at 24 hours after cross-clamp (8.2 +/- 8.5 microg/L vs 3.2 +/- 3.1 microg/L; p = 0.02). Patients with subtotal stenosis or occlusion of one or more main coronary arteries showed significantly lower cardiac troponin-I levels after retrograde application. CONCLUSIONS: Lower concentrations of the cardiac troponin-I marker after retrograde application of cardioplegia indicate advantages of myocardial protection in ischemic heart disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Coronary Artery Bypass -
- Creatine Kinase - blood
- Creatine Kinase, MB Form -
- Female -
- Heart Arrest, Induced - methods
- Humans -
- Isoenzymes - blood
- Male -
- Middle Aged -
- Prospective Studies -
- Troponin I - blood