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Selected Publication:
Aringer, M; Graninger, WB; Smolen, JS; Kiener, HP; Steiner, CW; Trautinger, F; Knobler, R.
Photopheresis treatment enhances CD95 (fas) expression in circulating lymphocytes of patients with systemic sclerosis and induces apoptosis.
Br J Rheumatol. 1997; 36(12):1276-1282
Doi: 10.1093/rheumatology/36.12.1276
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- Co-authors Med Uni Graz
- Graninger Winfried
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- Abstract:
- We investigated the effects of photopheresis in systemic sclerosis by analysing its influence on lymphocytes with regard to apoptosis and expression of bcl-2 and fas. Peripheral blood lymphocytes isolated immediately before and 24 h after photopheresis were investigated for apoptosis, bcl-2 and fas expression by fluorocytometry, and compared to controls. In addition, leucocytes from systemic sclerosis patients taken directly from the photopheresis system were tested for apoptosis after 24 h in culture. fas expression was similar in controls and patients with systemic sclerosis just before photopheresis, but increased 24 h after photopheresis, mainly due to an increase of CD4+CD95+ cells. bcl-2 was overexpressed in scleroderma peripheral lymphocytes, but not influenced by photopheresis. As compared to healthy controls, the percentage of apoptotic cells 24 h after photopheresis was high in cultured lymphocytes, but not ex vivo. The significant increase in fas on peripheral lymphocytes observed in this study may be a major operative mechanism of photopheresis in addition to (and possibly related to) the induction of apoptosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antigens, CD95 - metabolism
- Apoptosis -
- Cells, Cultured -
- Female -
- Humans -
- Lymphocyte Subsets - immunology
- Lymphocytes - immunology
- Male -
- Middle Aged -
- Photopheresis -
- Proto-Oncogene Proteins c-bcl-2 - metabolism
- Scleroderma, Systemic - immunology Scleroderma, Systemic - pathology Scleroderma, Systemic - therapy
- Find related publications in this database (Keywords)
- photopheresis
- CD95
- fas
- bcl-2
- lymphocytes
- systemic sclerosis
- apoptosis