Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Aringer, M; Stummvoll, GH; Steiner, G; Köller, M; Steiner, CW; Höfler, E; Hiesberger, H; Smolen, JS; Graninger, WB.
Serum interleukin-15 is elevated in systemic lupus erythematosus.
Rheumatology (Oxford). 2001; 40(8):876-881
Doi: 10.1093/rheumatology/40.8.876
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- Co-Autor*innen der Med Uni Graz
- Graninger Winfried
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- Abstract:
- OBJECTIVE: To investigate if interleukin-15 (IL-15) (rather than IL-2) is increased in systemic lupus erythematosus (SLE) and might be responsible for immunological abnormalities of SLE such as the increased lymphocytic expression of Bcl-2 and CD25. METHODS: Serum IL-15, IL-2 and tumour necrosis factor (TNF) levels of 65 SLE patients, 20 healthy persons and 10 rheumatoid arthritis (RA) patients were measured by enzyme-linked immunosorbent assay (ELISA). For 25 SLE patients, the percentage of CD25 + lymphocytes and the lymphocytic Bcl-2 levels were simultaneously determined by fluorocytometry. Peripheral blood mononuclear cells (PBMC) of 15 SLE patients were incubated with or without recombinant IL-15 and the influence on Bcl-2 and CD25 was determined. RESULTS: IL-15 was found to be elevated in 25 SLE sera (38%), but in none of the 20 healthy sera (P = 0.0005) and none of the 10 RA sera. Both lymphocyte CD25 and Bcl-2 expression significantly correlated with serum IL-15 and were increased by recombinant IL-15. CONCLUSION: Serum IL-15 may in part be responsible for the immunological abnormalities seen in active SLE.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Arthritis, Rheumatoid - immunology
- Female -
- Humans -
- Interleukin-15 - blood
- Lupus Erythematosus, Systemic - immunology
- Lymphocyte Activation -
- Male -
- Middle Aged -
- Proto-Oncogene Proteins c-bcl-2 - analysis
- Receptors, Interleukin-2 - analysis
- Tumor Necrosis Factor-alpha - analysis
- Find related publications in this database (Keywords)
- SLE
- IL-15
- IL-15R
- lymphocyte
- CD25
- Bcl-2
- IL-2
- TNF
- ELISA