Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Olschewski, A; Bräu, ME; Olschewski, H; Hempelmann, G; Vogel, W.
ATP-dependent potassium channel in rat cardiomyocytes is blocked by lidocaine. Possible impact on the antiarrhythmic action of lidocaine.
Circulation. 1996; 93(4):656-659
Doi: 10.1161/01.CIR.93.4.656
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- Führende Autor*innen der Med Uni Graz
- Olschewski Andrea
- Co-Autor*innen der Med Uni Graz
- Olschewski Horst
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- Abstract:
- BACKGROUND: During myocardial ischemia, lidocaine has favorable antiarrhythmic properties. Malignant arrhythmias result from heterogeneity between ischemic and nonischemic regions in extracellular potassium concentration and action potential duration. These effects have been attributed to the activation of ATP-dependent potassium (KATP) channels. In this study, we investigated the action of lidocaine on the KATP channels to test the possible link between the antiarrhythmic properties of lidocaine and its action on the KATP channel. METHODS AND RESULTS: The patch-clamp technique was employed on enzymatic dissociated cardiomyocytes of adult rats. Lidocaine was applied to the outer side of excised membrane patches by means of a multibarrel perfusion system. Lidocaine reversibly blocked the mean current of the KATP channels in a concentration-dependent manner (IC50 = 43 +/- 4.7 mumol/L, E = 0 mV, n = 6), while the amplitude of the single-channel current remained unchanged. The half-maximum blocking concentration corresponds to the therapeutic range for the antiarrhythmic application of a lidocaine bolus in humans. CONCLUSIONS: The open probability but not the conductance of the KATP channel in the membrane of rat cardiomyocytes is blocked by lidocaine. This action may explain, in part, the favorable antiarrhythmic properties of lidocaine during acute myocardial ischemia.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - metabolism
- Animals - metabolism
- Anti-Arrhythmia Agents - pharmacology
- Arrhythmia - drug therapy
- Humans - drug therapy
- Lidocaine - pharmacology
- Male - pharmacology
- Membrane Potentials - drug effects
- Myocardial Ischemia - drug therapy
- Potassium Channel Blockers - drug therapy
- Potassium Channels - drug effects
- Rats - drug effects
- Rats, Wistar - drug effects
- Find related publications in this database (Keywords)
- antiarrhythmia agents
- electrophysiology
- ischemia
- myocardial infarction
- potassium channel