Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Munstedt, K; Milch, W; Sachsse, S; Lang, U; Vahrson, H.
Subjective and objective parameters in the evaluation of treatment success in antiemetic prophylaxis of cancer chemotherapy
ONKOLOGIE 1997 20: 54-59.
Doi: 10.1159/000218897
Web of Science
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- Co-Autor*innen der Med Uni Graz
- Lang Uwe
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- Abstract:
- Background: In most antiemetic trials in patients receiving chemotherapy the subjective ratings of patients have not been considered in assessing the quality of antiemetic therapy. Based on the concept of self-psychology which implies that the importance of patients' truth and patients' experiences should be considered, we tried to establish the relevance and importance of subjective parameters. Patients and Method: 607 courses of PEC chemotherapy (cisplatinum 50 mg/m(2), epirubicin 60 mg/m(2), and cyclophosphamide 500 mg/m(2)) in patients with gynaecological malignancy and a high 'emetic risk score' were analysed using the Rotterdam Symptom Checklist and the GieBener Beschwerdebogen. Results: Significant correlations between objective and subjective parameters were found, however, on an individual basis low absolute values of vomiting and nausea episodes do not necessarily reflect patients' quality of life during treatment. Conclusions: Patients' subjective well-being rather than objective parameters determined tolerability of the treatment, and may contribute to patients' decisions as to whether to continue chemotherapy. Thus subjective well-being should be an essential part of clinical trials concerning antiemetic therapy.
- Find related publications in this database (Keywords)
- nausea
- vomiting
- antiemetic therapy
- chemotherapy