Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wedrich, A; Menapace, R; Ries, E; Polzer, I.
Intracameral tissue plasminogen activator to treat severe fibrinous effusion after cataract surgery.
J CATARACT REFRACT SURG 1997 23: 873-877.
Doi: 10.1016/S0886-3350(97)80246-5
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- Führende Autor*innen der Med Uni Graz
- Wedrich Andreas
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- Abstract:
- PURPOSE: To evaluate the efficacy and complications of intracameral recombinant tissue plasminogen activator (r-tPA) in the treatment of severe fibrinous effusion after cataract and combined cataract and glaucoma surgery. SETTING: University Eye Hospital Vienna, Austria. METHODS: In a prospective study, 40 eyes of 39 patients with severe fibrinous anterior chamber reaction in the early postoperative course received 25 microg r-tPA intracamerally through a temporal paracentesis. The main outcome measures were rate of complete fibrinolysis, time of maximal effect, and complications. RESULTS: Complete fibrinolysis occurred in 33 eyes (83%) after a mean of 3.2 hours +/- 0.9 (SD). The rate of complete fibrinolysis was higher in eyes having cataract surgery only (24 eyes, 89%) than in those having combined surgery (9 eyes, 69%). Recurrent fibrin was seen in 3 eyes (7%), small anterior chamber hemorrhage in 7 (18%), increased intraocular pressure in 3 (7%), and posterior synechias in 13 (33%). Complications were managed conservatively. CONCLUSION: The intracameral injection of 25 microg r-tPA proved to be a safe, efficient, and low-risk supplement in the treatment of severe postoperative fibrinous reactions.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Anterior Chamber - drug effects
- Female - drug effects
- Fibrinolysis - drug effects
- Follow-Up Studies - drug effects
- Glaucoma - surgery
- Humans - surgery
- Lenses, Intraocular - surgery
- Male - surgery
- Phacoemulsification - adverse effects
- Plasminogen Activators - administration and dosage
- Postoperative Complications - drug therapy
- Prospective Studies - drug therapy
- Recombinant Proteins - drug therapy
- Thrombolytic Therapy - drug therapy
- Tissue Plasminogen Activator - administration and dosage
- Trabeculectomy - adverse effects
- Treatment Outcome - adverse effects