Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lang, U; Baker, RS; Clark, KE.
Estrogen-induced increases in coronary blood flow are antagonized by inhibitors of nitric oxide synthesis.
EUR J OBSTET GYN REPROD BIOL 1997 74: 229-235.
Doi: 10.1016/S0301-2115(97)00104-8
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- Führende Autor*innen der Med Uni Graz
- Lang Uwe
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- Abstract:
- OBJECTIVE: Estrogen receptors have been found in coronary arterial endothelial and vascular smooth muscle cells. Therefore the present study was designed to determine if estradiol-17 beta can increase coronary blood flow and if so whether the changes are mediated by nitric oxide. STUDY DESIGN: Five oophorectomized non-pregnant sheep were chronically instrumented to measure blood pressure, heart rate, cardiac output, left circumflex coronary blood flow and central venous pressure. Animals received estradiol-17 beta (1.0 micrograms/kg) and cardiovascular responses were followed for 135 min. RESULTS: Estradiol-17 beta (1.0 micrograms/kg) increased left circumflex (coronary) blood flow 28 +/- 3%, cardiac output 15 +/- 1% and heart rate by 13 +/- 3%. Coronary vascular resistance decreased 23 +/- 5%, systemic vascular resistance decreased by 12 +/- 2% while blood pressure did not change significantly. Administration of the nitric oxide synthetase inhibitor L-nitroarginine methylester (L-NAME), had no effect on basal coronary blood flow but completely reversed estradiol-17 beta induced increases in coronary blood flow. CONCLUSION: These results demonstrate that estrogen increases coronary blood flow in the non-pregnant sheep and that L-NAME, an inhibitor of nitric oxide, is able to reverse the estrogen induced flow changes.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Flow Velocity - drug effects
- Blood Pressure - drug effects
- Coronary Circulation - drug effects
- Enzyme Inhibitors - pharmacology
- Estradiol - administration and dosage
- Female - administration and dosage
- Heart Rate - drug effects
- NG-Nitroarginine Methyl Ester - pharmacology
- Nitric Oxide - metabolism
- Nitric Oxide Synthase - antagonists and inhibitors
- Sheep - antagonists and inhibitors
- Find related publications in this database (Keywords)
- estradiol-17 beta
- coronary
- estrogens
- cardiac output