Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Villa, M.
Tissue Immunometabolism in Autoimmunity.
Eur J Immunol. 2026; 56(1):e70139
Doi: 10.1002/eji.70139
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- Führende Autor*innen der Med Uni Graz
- Villa Matteo
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- Abstract:
- Autoimmunity causes damage to organs targeted by the effector function of the immune response. The dynamics of autoimmunity in human peripheral tissues are not well understood due to the limited access to tissue samples. As cellular metabolism controls immune function, studying the crosstalk between the environment and cells within a tissue may provide information on how the metabolism of immune cells drives autoimmunity in peripheral tissues. In this review, I discuss some of the work that explored the complexity of the tissue environment, its sensing by cells in the tissue, and the consequences this has on cell and tissue functions, highlighting implications for autoimmune diseases. I also suggest a framework to study immunometabolism in tissues, contextualizing the metabolic choices of immune cells within the diversity of the extracellular environment they encounter.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Autoimmunity - immunology
- Animals - administration & dosage
- Autoimmune Diseases - immunology, metabolism