Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Edlinger, L; Egger, V; Riedl, JM.
Bridging the gap: targeted treatment strategies for cancer of unknown primary
MEMO-MAG EUR MED ONC. 2026;
Doi: 10.1007/s12254-025-01099-4
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Edlinger Leo
- Co-Autor*innen der Med Uni Graz
- Egger Valentina
- Riedl Jakob
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- Abstract:
- The advent of comprehensive genomic profiling has revolutionized not only the identification of the tissue of origin in cancer of unknown primary (CUP) but also enabled the detection of potentially actionable molecular alterations. Recent evidence demonstrates that molecularly targeted therapies improve outcomes in patients with unfavorable CUP harboring such alterations. This review summarizes current methods for determining the tissue of origin and discusses recent clinical trials evaluating molecularly guided therapies in unfavorable CUP.
- Find related publications in this database (Keywords)
- Molecular tumor board
- Tissue of origin
- Comprehensive genomic profiling
- Next-generation sequencing
- Targeted therapy