Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lang, U; Baker, RS; Khoury, J; Clark, KE.
Effects of chronic reduction in uterine blood flow on fetal and placental growth in the sheep.
AMER J PHYSIOL-REGUL INTEGR C 2000 279: R53-R59.
Doi: 10.1152/ajpregu.2000.279.1.R53
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- Führende Autor*innen der Med Uni Graz
- Lang Uwe
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- Abstract:
- Pregnancy is associated with a significant increase in uteroplacental blood flow (UBF), which is responsible for delivering adequate nutrients and oxygen for fetal and placental growth. The present study was designed to determine the effects of vascular insufficiency on fetal and placental growth. Thirty-nine late-term pregnant ewes were instrumented to investigate the effects of chronic UBF reduction. Animals were split into three groups based on uterine blood flow, and all animals were killed on gestational day 138. UBF, which began at 851 +/- 74 ml/min (n = 39), increased in controls (C) to 1,409 +/- 98 ml/min (day 138 of gestation) and in the moderately restricted (R(M)) group to 986 +/- 69 ml/min. In the severely restricted (R(S)) group, UBF was only 779 +/- 79 ml/min on gestational day 138. This reduction in UBF significantly affected fetal body weight with R(M) fetuses weighing 3,685 +/- 178 g and R(S) fetuses weighing 2,920 +/- 164 g compared with C fetal weights of 4,318 +/- 208 g. Fetal brain weight was not affected, whereas ponderal index was significantly reduced in R(M) (2.94 +/- 0.09) and R(S) fetuses (2.49 +/- 0.08) compared with the value of the C fetuses (3.31 +/- 0.08). Placental weight was also significantly reduced in the R(M) group, being 302 +/- 24 g, whereas the R(S) group placenta weighed 274 +/- 61 g compared with the C values of 414 +/- 57 g. Fetal heart, liver, lung, and thymus were all significantly smaller in the R(S) group. Thus the present study shows a clear relationship between the level of UBF and both fetal and placental size. Furthermore, the observation that fetal brain weight was not affected, whereas fetal body weight was significantly reduced suggests that this experimental preparation may provide a useful model in which to study asymmetric fetal growth restriction.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Body Weight -
- Embryonic and Fetal Development -
- Female -
- Fetal Growth Retardation - etiology
- Fetal Weight - etiology
- Gestational Age - etiology
- Liver - pathology
- Lung - pathology
- Myocardium - pathology
- Organ Size - pathology
- Placenta - growth and development
- Pregnancy - growth and development
- Regional Blood Flow - growth and development
- Sheep - growth and development
- Thymus Gland - pathology
- Uterus - blood supply
- Find related publications in this database (Keywords)
- placenta
- fetus
- fetal growth restriction
- intrauterine growth restriction