Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Krepler, K; Kruger, A; Tittl, M; Stur, M; Wedrich, A.
Intravitreal injection of tissue plasminogen activator and gas in subretinal hemorrhage caused by age-related macular degeneration.
RETINA-J RETIN VITR DIS 2000 20: 251-256.
Doi: 10.1097/00006982-200005000-00004
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Wedrich Andreas
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- Abstract:
- PURPOSE: To assess the efficacy and safety of intravitreal injection of recombinant tissue plasminogen activator and sulfur hexafluoride gas for displacement of subretinal hemorrhages in patients with age-related macular degeneration. METHODS: The authors injected 25 microg of recombinant tissue plasminogen activator and 0.5 mL sulfur hexafluoride gas intravitreally in 11 patients with subretinal hemorrhages of less than 3 weeks duration. Anatomic and functional results were evaluated. RESULTS: Displacement of subretinal blood was successful within the first week after surgery in 10 of 11 patients. This was accompanied by visual improvement in eight patients. After 1 year, visual acuity was better than before surgery in five patients. Diagnosis of a choroidal neovascularization by fluorescein angiography was possible in all patients, and was treated with laser photocoagulation in five. The authors observed no adverse effects of treatment. CONCLUSION: Recombinant tissue plasminogen activator and gas effectively displace subretinal blood in patients with age-related macular degeneration. Randomized studies are necessary to prove the benefit of this simple and safe method in patients with subretinal hemorrhage due to age-related macular degeneration.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Female -
- Fibrinolytic Agents - therapeutic use
- Fluorescein Angiography - therapeutic use
- Humans - therapeutic use
- Injections - therapeutic use
- Macular Degeneration - complications
- Male - complications
- Pilot Projects - complications
- Recombinant Proteins - therapeutic use
- Retinal Hemorrhage - drug therapy
- Sulfur Hexafluoride - administration and dosage
- Thrombolytic Therapy - administration and dosage
- Tissue Plasminogen Activator - therapeutic use
- Visual Acuity - therapeutic use
- Vitreous Body - therapeutic use
- Find related publications in this database (Keywords)
- age-related macular degeneration
- subretinal hemorrhage
- tissue plasminogen activator