Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zoma, W; Baker, RS; Lang, U; Clark, KE.
Hemodynamic response to tibolone in reproductive and nonreproductive tissues in the sheep.
AMER J OBSTET GYNECOL 2001 184: 544-551.
Doi: 10.1067/mob.2001.111098
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Lang Uwe
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- Abstract:
- OBJECTIVE: We sought to determine the hemodynamic effects of tibolone in reproductive and nonreproductive tissues in the nonpregnant ovariectomized sheep.Study Design: Six ewes were chronically instrumented for measurement of mean arterial pressure, heart rate, cardiac output, and coronary and uterine blood flow. A dose response curve was generated for intravenous tibolone (1.25, 2.5, and 5 mg) and compared with intravenous 17beta-estradiol (1 microg/kg body weight). To determine whether tibolone-related cardiovascular responses were estrogen receptor mediated and produced by nitric oxide, animals were treated on separate days with either estrogen receptor antagonist ICI 182,780 or the nitric oxide synthase inhibitor, L -nitroarginine methyl ester. RESULTS: Tibolone significantly increased coronary blood flow in a dose-related fashion by 5% +/- 3%, 9% +/- 2%, and 11% +/- 2% for the 1.25, 2.5, and 5 mg doses, respectively. Uterine blood flow was also increased significantly in a dose-dependent manner by 98 +/- 15, 216 +/- 59, and 303 +/- 56 mL/min, for the 1.25, 2.5, and 5 mg doses, respectively. L -Nitroarginine methyl ester attenuated tibolone-induced increases in uterine blood flow by 84% +/- 4% and abolished the increase in coronary blood flow. ICI 182,780 inhibited all tibolone-induced cardiovascular responses. CONCLUSION: Tibolone significantly increases coronary and uterine blood flow in ovariectomized ewes. The coronary and uterine vascular responses are mediated via an estrogen receptor-dependent mechanism and are produced mainly by nitric oxide.
- Find related publications in this database (using NLM MeSH Indexing)
- Anabolic Agents - administration and dosage
- Animals - administration and dosage
- Cardiac Output - drug effects
- Coronary Circulation - drug effects
- Dose-Response Relationship, Drug - drug effects
- Enzyme Inhibitors - pharmacology
- Estradiol - administration and dosage
- Estrogen Replacement Therapy - administration and dosage
- Female - administration and dosage
- Heart Rate - drug effects
- Hemodynamic Processes - drug effects
- Kinetics - drug effects
- NG-Nitroarginine Methyl Ester - pharmacology
- Nitric Oxide Synthase - antagonists and inhibitors
- Norpregnenes - administration and dosage
- Sheep - administration and dosage
- Uterus - blood supply
- Find related publications in this database (Keywords)
- tibolone
- blood flow
- estrogen receptor antagonist
- nitric oxide
- sheep