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Lang, U; Zygmunt, M; Kunzel, W; Clark, KE.
Fetal growth restriction in animal models
GYNAKOLOGE 2001 34: 820-+. Doi: 10.1007/s001290101084
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Leading authors Med Uni Graz: Lang Uwe
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Abstract:: In addition to genetic components, fetal growth is predominantly determined by uterine perfusion and the resulting supply of nutrients and oxygen. If there is a chronic reduction in uterine blood supply or if the natural increase in uterine perfusion during the course of pregnancy does not take place, growth is hindered and the fetus is put at risk. Among the great number of experimental models of intrauterine growth restriction, those involving a generalised reduction in the uteroplacental blood supply are of significance to questions relating to human pregnancy, Despite physiological differences, particularly with regard to maternal metabolism and placentation, the occlusion model in the pregnant sheep is suitable for investigating questions about fetal and placental growth, nutrient transfer and the fetal oxygen economy.
Find related publications in this database (Keywords): fetal growth restriction; uteroplacental blood supply; occlusion model