Medizinische Universität Graz - Research portal
Selected Publication:
Zygmunt, M; Munstedt, K; Lang, U.
The role of vasculo- and angiogenesis in embryonic and fetal development. A short review
GYNAKOLOGE 2001 34: 812-+.
Doi: 10.1007/s001290101088
Web of Science
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- Co-authors Med Uni Graz
- Lang Uwe
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- Abstract:
- The investigation of the mechanisms regulating the development of new vessels is crucial to our understanding of both tumor biology and the early development of pregnancy. There are striking similarities between tumor invasion and vascularization on the one hand and blastocyst implantation and placental development on the other. Both sets of events share two important features: migration and invasion through the extracellular matrix and the ability to access the host vascular system and recruit blood supply. Despite these common features, at least two major differences occur. First, invasion and new vessel formation during pregnancy is self-limited compared to the uncontrolled tumor growth and vessel formation during oncogenesis. Second, the implanting embryo not only accesses the maternal vascular system, but also forms its own vascular system. Our understanding of the different molecular and functional aspects of these two processes, in particular the self-limitation of trophoblastic invasion and vessel formation during gestation, might allow the development of new therapeutic strategies for the treatment of both tumors and tumor and pregnancy related pathology. This short review provides a general overview of the recent work on vascular development during early pregnancy and its role in the pathogenesis of pregnancy related disorders.
- Find related publications in this database (Keywords)
- vasculo- and angiogenesis
- growth retardiation
- pregnancy related disorders