Medizinische Universität Graz - Research portal
Selected Publication:
Schulz, R; Baseler, G; Ghofrani, HA; Grimminger, F; Olschewski, H; Seeger, W.
Nocturnal periodic breathing in primary pulmonary hypertension.
Eur Respir J. 2002; 19(4):658-663
Doi: 10.1183/09031936.02.00225102
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-authors Med Uni Graz
- Olschewski Horst
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Cheyne-Stokes respiration is frequently observed in congestive heart failure. Among other factors, prolongation of circulation time, hypocapnia and hypoxia are thought to underlie this sleep-related breathing disorder. Primary pulmonary hypertension (PPH) is also characterized by reduced cardiac output and blood gas alterations. Therefore, the aim of the present study was to determine whether a nocturnal periodic breathing (PB) occurs in PPH. A total of 20 consecutive patients with PPH who had been admitted for pharmacological investigation of pulmonary vasoreactivity were investigated by lung function testing, right heart catheterization and full-night attended polysomnography. PB was detected in six patients (30%) (mean +/- SEM: apnoea/hypopnoea index 37 +/- 5 h(-1); arterial oxygen saturation was <90% during 56 +/- 6.5% of total sleep time). The patients with PB had more severe haemodynamic impairment than those without. They also had a more marked reduction in the pulmonary diffusion capacity and greater arterial hypoxia. PB was markedly improved or even eradicated by nasal oxygen during the night. Periodic breathing occurs in patients with advanced primary pulmonary hypertension and can be reversed by nocturnal nasal oxygen. The clinical and prognostic significance of periodic breathing in primary pulmonary hypertension needs to be determined by further studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Cheyne-Stokes Respiration - diagnosis
- Female - diagnosis
- Heart Catheterization - diagnosis
- Humans - diagnosis
- Hypertension, Pulmonary - physiopathology
- Male - physiopathology
- Middle Aged - physiopathology
- Oxygen Inhalation Therapy - physiopathology
- Polysomnography - physiopathology
- Respiratory Function Tests - physiopathology
- Find related publications in this database (Keywords)
- primary pulmonary
- hypertension
- sleep disordered breathing