Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Sator-Katzenschlager, SM; Oehmke, MJ; Kontaratos, M; Wedrich, A; Heinze, G; Weinstabl, C.
Effect of different doses of cisatracurium on intraocular pressure in sedated patients.
EUR J ANAESTH 2002 19: 823-828.
Doi: 10.1017/S0265021502001333
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Wedrich Andreas
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- Abstract:
- BACKGROUND AND OBJECTIVE: The aim was to examine the course of intraocular pressure after relaxation with different doses of cisatracurium. METHODS: The investigation was carried out as a prospective, randomized double-blind study in a crossover design in 30 postoperative patients with stable haemodynamic and respiratory function (ASA I and II). To exclude any disrupting factors, patients remained intubated and continuously sedated. Twenty patients received an intubation dose (2 x ED95) of cisatracurium (0.1 mg kg(-1)) compared with atracurium (0.5 mg kg(-1)). In a second series, 10 patients were given an effective dose, ED95 (0.05 mg kg(-1)), and a repeat dose (0.02 mg kg(-1)) of cisatracurium. The intraocular pressure was determined before (T0) as well as 1 (T1), 5 (T5), 10 (T10), 15 (T15), 20 (T20) and 45 (T45) min after bolus administration. RESULTS: Intraocular pressure decreased after an intubation dose of either cisatracurium or atracurium, and reached a minimum after 10 min (6.7 +/- 2.2 and 7.9 +/- 2.1 mmHg, respectively). There was no significant difference between either muscle relaxant (P = 0.27). When lower doses of cisatracurium (0.05 and 0.02 mg kg(-1)) were applied, the intraocular pressure also decreased, albeit to a lesser extent and with a delayed onset (8.4 +/- 1.9 mmHg after 10 min, 9.9 +/- 3.4 mmHg after 15 min). There was no significant difference between dosages (p = 0.44). CONCLUSIONS: Cisatracurium is a useful drug in patients when a decrease of intraocular pressure is wanted and where muscle relaxation is necessary and acceptable.
- Find related publications in this database (using NLM MeSH Indexing)
- Atracurium - administration and dosage
- Carbon Dioxide - blood
- Conscious Sedation - blood
- Cross-Over Studies - blood
- Double-Blind Method - blood
- Female - blood
- Hemodynamic Processes - drug effects
- Humans - drug effects
- Intraocular Pressure - drug effects
- Male - drug effects
- Middle Aged - drug effects
- Neuromuscular Nondepolarizing Agents - administration and dosage
- Oxygen - blood
- Prospective Studies - blood
- Find related publications in this database (Keywords)
- neuromuscular non-depolarizing agents
- atracurium
- cisatracurium
- ocular physiology
- intraocular pressure