Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Degreef, H; del Palacio, A; Mygind, S; Ginter, G; Pinto Soares, A; Zuluaga de Cadena, A.
Randomized double-blind comparison of short-term itraconazole and terbinafine therapy for toenail onychomycosis.
Acta Derm Venereol. 1999; 79(3):221-223
Doi: 10.1080%2F000155599750011020
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- Ginter-Hanselmayer Gabriele
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- Abstract:
- Previous studies evaluating short-term itraconazole and terbinafine therapy for onychomycosis have varied in protocol and size; this double-blind study enabled a large-scale, standardized, direct comparison. Patients with toenail onychomycosis were randomized to itraconazole 200 mg daily (n = 146) or terbinafine 250 mg daily (n = 146) for 12 weeks, with a 36-week follow-up. Mycological cure rates at the follow-up end-point were significantly equivalent (61% with itraconazole vs. 67% with terbinafine). A similar proportion of patients in each group experienced adverse events during treatment (itraconazole, 22%; terbinafine, 23%). More patients receiving terbinafine stopped treatment permanently because of treatment-related adverse events (8% vs. 1%).
- Find related publications in this database (using NLM MeSH Indexing)
- Abdominal Pain - chemically induced
- Adolescent - chemically induced
- Adult - chemically induced
- Aged - chemically induced
- Antifungal Agents - adverse effects
- Double-Blind Method - adverse effects
- Dyspepsia - chemically induced
- Female - chemically induced
- Foot Dermatoses - drug therapy
- Headache - chemically induced
- Humans - chemically induced
- Itraconazole - adverse effects
- Male - adverse effects
- Middle Aged - adverse effects
- Naphthalenes - adverse effects
- Nausea - chemically induced
- Onychomycosis - drug therapy
- Taste Disorders - chemically induced
- Treatment Outcome - chemically induced
- Trichophyton - drug effects
- Virus Diseases - chemically induced
- Find related publications in this database (Keywords)
- Antifungal Agents
- Dermatophytosis
- Efficacy
- Safety
- Tolerability