Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cavigioli, F; Davies, IM; Lista, G; Lee, K; Wallace, MJ; Kitchen, MJ; Jurkschat, D; Binder-Heschl, C; Te, Pas, A; Hooper, SB; Crossley, KJ.
Surfactant enhances the distribution of ventilation in partially aerated lungs of preterm rabbits.
J Appl Physiol (1985). 2025;
Doi: 10.1152/japplphysiol.00534.2025
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- Binder-Heschl Corinna
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- Abstract:
- In very preterm infants, non-uniform lung aeration occurs when regions of the immature lung remain liquid-filled after birth, which restricts gas exchange to aerated lung regions. We have examined the effect of surfactant administration on the uniformity of lung aeration and the distribution of ventilation in mechanically ventilated preterm rabbits. Preterm kittens (28-29 days gestation; term ~32 days) were delivered by caesarean section and intubated via tracheostomy. Prior to the experiment, kittens were initially ventilated (intermittent positive pressure ventilation; iPPV) to achieve whole (both lungs) or partial (one lung) lung aeration. Kittens were then ventilated (volume targeted 8 mL/kg) with or without an initial sustained inflation (SI), before surfactant. Lung aeration was measured before and after surfactant, using phase contrast X-ray imaging and plethysmography. iPPV alone was unable to aerate unaerated lung regions, resulting in regional over-expansion due to a marked non-uniform distribution of ventilation. While a SI increased aeration of non-aerated lung regions, the effect of surfactant was markedly greater, resulting in aeration of previously unaerated lung regions and markedly reducing regional over-expansion. Surfactant administration soon after birth greatly increases the uniformity of lung aeration and distribution of ventilation in mechanically ventilated very preterm newborns.