Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Douschan, P; Kaemmerer-Suleiman, AS; Egenlauf, B; Seyfarth, HJ; Zeder, K; Mayer, L; Wissmüller, M; Heberling, M; Huntgeburth, M; Barnikel, M; Xanthouli, P; Sorichter, S; John, T; Ulrich, S; Kovacs, G.
Definition and Classification of Pulmonary Hypertension
PNEUMOLOGIE. 2025; 79(10): 723-731.
Doi: 10.1055/a-2625-4769
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Douschan Philipp
- Co-Autor*innen der Med Uni Graz
- John Teresa
- Kovacs Gabor
- Zeder Katarina Eleonora
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- Abstract:
- Pulmonary Hypertension (PH) is characterized as a hemodynamic disorder defined by a mean pulmonary arterial pressure (mPAP) exceeding 20 mmHg at rest. Classification into distinct subtypes is guided by measurements of pulmonary arterial wedge pressure (PAWP) and pulmonary vascular resistance (PVR): Precapillary PH: PAWP <= 15 mmHg accompanied by PVR > 2 Wood Units (WU), isolated Postcapillary PH: PAWP > 15 mmHg with PVR <= 2 WU and combined Pre- and Postcapillary PH: PAWP > 15 mmHg with PVR > 2 WU.Exercise-Induced PH refers to a pathophysiological condition in which resting mPAP is within normal limits but exhibits an exaggerated rise during physical exertion. This is quantified by a slope of mPAP relative to cardiac output exceeding 3 mmHg per liter per minute between rest and activity.The foundational framework for the clinical classification of PH, comprising five principal groups, remains unchanged. Nevertheless, several updates have been introduced: Reintegration of long-term responders to calcium channel blockers as a distinct subset within idiopathic pulmonary arterial hypertension (IPAH), Inclusion of new subcategories under Group 2 PH, which encompasses PH associated with left heart disease and Revision of Group 3 PH to categorize patients based on underlying pulmonary pathology rather than solely functional impairment.Additionally, Mitomycin-C and Carfilzomib have been recognized as pharmacologic agents with a confirmed causal relationship to the development of pulmonary arterial hypertension (PAH) and have thus been added to the list of definitively associated drugs.
- Find related publications in this database (Keywords)
- hemodynamics
- exercise PH
- PH subgroups
- exercise PH
- PH subgroups