Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
El-Mahrouk, M; Marino, R; Corallino, D; Artuso, V; Cipriani, F; Catena, M; Sucher, R; Aldrighetti, L; Ratti, F.
Clinical and biological impact of conversion on outcomes of minimally invasive liver surgery: a multimodal analysis
UPDATES SURG. 2025;
Doi: 10.1007/s13304-025-02375-y
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- El-Mahrouk Mohamed
- Co-Autor*innen der Med Uni Graz
- Sucher Robert
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- Abstract:
- Minimally invasive liver surgery (MILS) offers several advantages over open liver surgery (OLS), but the underlying mechanisms remain unclear. This study compares inflammatory marker levels between OLS and MILS and examines the impact of conversion. Patients undergoing liver resection at San Raffaele Hospital (September 2022-May 2023) were prospectively enrolled. Plasma inflammatory markers were measured over 120 postoperative hours and analyzed between cohorts. Among 118 liver resections (50 laparoscopic, 38 robotic, 30 open), the OLS group showed higher intraoperative plasma lactate (4.6 vs. 3.8 mmol/L; p < 0.04) and levels one hour postoperatively (3.9 vs. 2.4 mmol/L; p = 0.02). CRP and IL-6 levels were significantly higher in OLS (p < 0.001). No significant differences were found between laparoscopic and robotic approaches. However, conversion led to increased lactate (p = 0.018), CRP (p < 0.05), and IL-6 (p < 0.001) also compared with upfront OLS. MILS significantly improves biological markers as compared to OLS. However, conversion not only negates these benefits but also amplifies surgical stress and inflammation.
- Find related publications in this database (Keywords)
- Hepatobiliary surgery
- Minimal-invasive surgery
- Robotic surgery
- Inflammatory biomarkers