Medizinische Universität Graz - Research portal
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SHR Neuro Cancer Cardio Lipid Metab Microb
Piani, F; Melena, I; Severn, C; Chung, LT; Vinovskis, C; Cherney, D; Pyle, L; Roncal-Jimenez, CA; Lanaspa, MA; Rewers, A; van, Raalte, DH; Obeid, W; Parikh, C; Nelson, RG; Pavkov, ME; Nadeau, KJ; Johnson, RJ; Bjornstad, P.
Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study.
Pediatr Diabetes. 2021; 22(7):1031-1039
Doi: 10.1111/pedi.13259
[OPEN ACCESS]
PubMed
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- Piani Federica
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- Abstract:
- OBJECTIVE: Glomerular injury is a recognized complication of diabetic ketoacidosis (DKA), yet the tubular lesions are poorly understood. The aim of this prospective study was to evaluate the presence and reversibility of tubular injury during DKA in children with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Blood and urine samples were collected from 40 children with DKA (52% boys, mean age 11 ± 4 years, venous pH 7.2 ± 0.1, glucose 451 ± 163 mg/dL) at three timepoints: 0-8 and 12-24 h after starting insulin, and 3 months after discharge. Mixed-effects models evaluated the changes in tubular injury markers over time (neutrophil gelatinase-associated lipocalin [NGAL], kidney injury molecule 1 [KIM-1], and interleukin 18 [IL-18]). We also evaluated the relationships among the tubular injury biomarkers, copeptin, a vasopressin surrogate, and serum uric acid (SUA). RESULTS: Serum NGAL, KIM-1, and IL-18 were highest at 0-8 h (306.5 ± 45.9 ng/mL, 128.9 ± 10.1 pg/mL, and 564.3 ± 39.2 pg/mL, respectively) and significantly decreased over 3 months (p = 0.03, p = 0.01, and p < 0.001, respectively). There were strong relationships among increases in copeptin and SUA and rises in tubular injury biomarkers. At 0-8 h, participants with acute kidney injury (AKI) [17%] showed significantly higher concentrations of tubular injury markers, copeptin, and SUA. CONCLUSIONS: DKA was characterized by tubular injury, and the degree of injury associated with elevated copeptin and SUA. Tubular injury biomarkers, copeptin and SUA may be able to predict AKI in DKA.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Kidney Injury - etiology, physiopathology
- Adolescent - administration & dosage
- Biomarkers - blood
- Child - administration & dosage
- Diabetes Mellitus, Type 1 - complications
- Diabetic Ketoacidosis - complications, physiopathology
- Diabetic Nephropathies - complications, physiopathology
- Female - administration & dosage
- Glomerular Filtration Rate - administration & dosage
- Glycopeptides - blood
- Humans - administration & dosage
- Kidney Tubules - physiopathology
- Male - administration & dosage
- Severity of Illness Index - administration & dosage
- Uric Acid - blood