Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Piani, F; Tossetta, G; Fantone, S; Agostinis, C; Di, Simone, N; Mandalà, M; Bulla, R; Marzioni, D; Borghi, C.
First Trimester CD93 as a Novel Marker of Preeclampsia and Its Complications: A Pilot Study.
High Blood Press Cardiovasc Prev. 2023; 30(6):591-594
Doi: 10.1007/s40292-023-00608-y
PubMed
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- Abstract:
- INTRODUCTION: CD93 plays a crucial role in endothelial homeostasis and angiogenesis. Recently its role in hypertension has been investigated, holding promise for novel targeted diagnostic and therapeutic strategies. AIM: We assessed for the first time differences in first trimester serum CD93 levels in women who lately developed preeclampsia (PE) vs. normotensive pregnancy (NP). METHODS: First trimester serum CD93 concentrations were assessed in a multicenter cohort of 83 women (34 PE and 49 NP) by ELISA Immunoassay. RESULTS: Serum CD93 was lower in women who developed PE vs. NP (111.8 ± 24.4 vs. 137.5 ± 22.3 ng/ml; p < 0.001). Serum CD93 was associated with a decreased risk of developing PE (OR 0.950, 95% CI 0.922-0.978) and composite neonatal outcome (OR 0.952, CI 0.923-0.982), after adjustment for confounders. CONCLUSIONS: PE is accompanied by decreased serum CD93 levels. CD93 might play a role during placentation leading to defective angiogenesis, vascular dysfunction, and PE development.
- Find related publications in this database (using NLM MeSH Indexing)
- Female - administration & dosage
- Humans - administration & dosage
- Infant, Newborn - administration & dosage
- Pregnancy - administration & dosage
- Biomarkers - administration & dosage
- Blood Pressure - administration & dosage
- Case-Control Studies - administration & dosage
- Hypertension - administration & dosage
- Pilot Projects - administration & dosage
- Pre-Eclampsia - diagnosis
- Pregnancy Trimester, First - administration & dosage