Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Seidl, M; Haghighi, EB; Lösslein, AK; Hufnagel, M; Lohrmann, F; Schneider, C; Kohlfürst, DS; Zenz, W; Gorkiewicz, G; Feiterna-Sperling, C; Krüger, R; Bronsert, P; Neppl, C; Sommer, KZ; Stehl, V; Boerries, M; Kuntz, M; Henneke, P.
Immunopathogenic and clinical implications of advanced tissue analysis in non-tuberculous mycobacterial infections in children
FRONT IMMUNOL. 2025; 16: 1597074
Doi: 10.3389/fimmu.2025.1597074
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- Co-Autor*innen der Med Uni Graz
- Gorkiewicz Gregor
- Kohlfürst Daniela
- Zenz Werner
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- Abstract:
- Objectives Infections with non-tuberculous mycobacteria (NTM) in children usually affect the lymph nodes and surrounding tissue. Although the infection is typically self-limiting, it carries a substantial risk of complications due to persistent inflammation and invasive therapeutic interventions. Yet, the immunopathogenesis of the disease is obscure, as are biomarkers guiding treatment decisions.Methods In this observational study, we analyzed histological samples collected in the NTMkids study to identify parameters associated with impaired wound healing and complicated disease progression. Samples from 33 patients (median age at first presentation 33 months) were investigated, with two consecutive biopsies in 9 patients.Results Germinal centers, a scattered distribution of granuloma associated CD4+ T-cells, higher CD8+ T-cell density inside the necrosis and foamy epitheloid cells were associated with a favorable outcome. Tissue damage presenting clinically as liquefaction was associated with an adverse outcome.Conclusions The identified tissue reaction patterns in NTM infections provide insights into the biology of NTM lymphadenitis in children and may aid in more precise treatment decisions.
- Find related publications in this database (Keywords)
- non-tuberculous mycobacteria
- lymphadenitis
- granuloma
- giant cells
- children
- complications
- histology