Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schwinger, W; Weber-Mzell, D; Zois, B; Rojacher, T; Benesch, M; Lackner, H; Dornbusch, HJ; Sovinz, P; Moser, A; Lanzer, G; Schauenstein, K; Ofner, P; Handgretinger, R; Urban, C.
Immune reconstitution after purified autologous and allogeneic blood stem cell transplantation compared with unmanipulated bone marrow transplantation in children.
Br J Haematol. 2006; 135(1):76-84
Doi: 10.1111/j.1365-2141.2006.06244.x
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- Führende Autor*innen der Med Uni Graz
- Schwinger Wolfgang
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Dornbusch Hans Jürgen
- Lackner Herwig
- Lanzer Gerhard
- Nebl Andrea Maria
- Ofner-Kopeinig Petra
- Ritter-Sovinz Petra
- Sperl Daniela Ingrid
- Urban Ernst-Christian
- Wendelin Gerald
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- Abstract:
- Immune reconstitution is critical for the long-term success of haematopoietic stem cell transplantation (HSCT). We prospectively analysed immune reconstitution parameters after transplantation of autologous (group 1; n = 10) and allogeneic (group 2; n = 12) highly purified CD34+ peripheral blood stem cells (PBSC) and unmanipulated allogeneic bone marrow (BM) (group 3; n = 9) in children. Median follow-up after HSCT was 56 (group 1), 61 (group 2), and 40.5 months (group 3). Median CD34-cell dose transplanted in the three groups was 9.4 x 10(6)/kg, 20.3 x 10(6)/kg, and 4.25 x 10(6)/kg recipient's body weight (BW) respectively. Complete haematopoietic engraftment was seen in all patients without any significant differences between the three groups. T-cell reconstitution at 6 months was significantly delayed in autologous peripheral blood stem cell transplantation (PBSCT) compared with allogeneic BM transplantation (P < 0.028) and allogeneic PBSCT (P < 0.034). At 3 months after transplantation numbers of CD56+/3- natural killer cells were higher in the allogeneic PBSC group (P < 0.01) compared with the BM group. The numbers of proven bacterial and viral infections were equally distributed between the three groups. In conclusion, recipients of allogeneic highly purified CD34+ PBSC or unmanipulated BM have higher lymphocyte subset counts at 6 months after transplantation than recipients of autologous CD34-selected PBSC. Infection rates and outcome, however, were not significantly different.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antigens, CD34 - blood
- Bone Marrow Transplantation - immunology
- Child -
- Child, Preschool -
- Female -
- Follow-Up Studies -
- Graft Survival - immunology
- Graft vs Host Disease - prevention & control
- Hematologic Diseases - immunology
- Humans -
- Immunity, Cellular -
- Immunocompromised Host -
- Infant -
- Killer Cells, Natural - immunology
- Lymphocyte Count -
- Male -
- Neoplasms - immunology
- Opportunistic Infections - immunology
- Peripheral Blood Stem Cell Transplantation -
- Prospective Studies -
- T-Lymphocyte Subsets - immunology
- Transplantation, Autologous -
- Transplantation, Homologous -