Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Skok, K; Maccio, U; Martin, SD; Bräutigam, K.
Tumor-Infiltrating Lymphocytes in Breast and Female Genital Tract Cancers: Overlooked Potential and Unexplored Frontiers.
Cancer Med. 2025; 14(13): e71023
Doi: 10.1002/cam4.71023
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- Führende Autor*innen der Med Uni Graz
- Skok Kristijan
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- Abstract:
- BACKGROUND: The growing success of cancer immunotherapies has led to significant advances in oncology. However, despite these promising developments, cancer-related mortality remains high for common cancer types such as breast and lower female genital tract cancers. METHOD: Here, we synthesize recent findings on the prognostic relevance of tumor-infiltrating lymphocytes (TILs) in breast, endometrial, tubo-ovarian, and vulvar cancer. Our analysis covers the relationship between TIL counts and density, immune cell subtype combinations, immunotherapy approaches, and patient outcomes. RESULTS: High TIL infiltration, especially CD8+ T-cells, generally correlates with improved outcomes such as in endometrial cancer (especially the POLE-ultramutated subgroup), invasive breast cancer, and ovarian epithelial tumors. However, in ductal carcinoma in situ (DCIS) of the breast, elevated TIL counts are linked to a worse prognosis. Ethnicity, the tumor microenvironment (TME), and molecular profiles further complicate the prognostic utility of TILs. CONCLUSIONS: TIL-based therapies have shown potential in personalized immunotherapy, particularly in recurrent, refractory ovarian cancer. Limited research on rarer gynecologic tumors hinders broader clinical applications.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Lymphocytes, Tumor-Infiltrating - immunology, metabolism
- Breast Neoplasms - immunology, therapy, pathology, mortality
- Tumor Microenvironment - immunology
- Genital Neoplasms, Female - immunology, therapy, pathology, mortality
- Prognosis - administration & dosage
- Immunotherapy - methods
- Find related publications in this database (Keywords)
- breast cancer
- endometrial cancer
- fallopian tube
- immunotherapy
- ovarian cancer
- review
- tumor microenvironment (TME)
- tumor-infiltrating lymphocytes (TILs)
- vulvar cancer