Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wolf, S; Deuel, JW; Hollmén, M; Felmerer, G; Kim, BS; Vasella, M; Grünherz, L; Giovanoli, P; Lindenblatt, N; Gousopoulos, E.
A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedema.
Int J Mol Sci. 2021; 22(7):
Doi: 10.3390/ijms22073313
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- Führende Autor*innen der Med Uni Graz
- Wolf Stefan Julian
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- Abstract:
- Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass index (BMI)-matched control patients. Both tissue groups showed no significant changes regarding lipid composition. As hyperplastic adipose tissue represents low-grade inflammation, the potential systemic effects on circulating cytokines were evaluated in lipedema and control patients using the Multiplex immunoassay system. Interestingly, increased systemic levels of interleukin 11 (p = 0.03), interleukin 28A (p = 0.04) and interleukin 29 (p = 0.04) were observed. As cytokines can influence metabolic activity, the metabolic phenotype of the stromal vascular fraction was examined, revealing significantly increased mitochondrial respiration in lipedema. In conclusion, despite sharing a comparable lipid profile with healthy adipose tissue, lipedema is characterized by a distinct systemic cytokine profile and metabolic activity of the stromal vascular fraction.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - metabolism
- Adult - administration & dosage
- Biomarkers - metabolism
- Biopsy - administration & dosage
- Body Mass Index - administration & dosage
- Cytokines - metabolism
- Female - administration & dosage
- Humans - administration & dosage
- Immunoassay - administration & dosage
- Inflammation - administration & dosage
- Lipedema - metabolism
- Lipid Metabolism - administration & dosage
- Lipidomics - administration & dosage
- Lipids - chemistry
- Male - administration & dosage
- Mass Spectrometry - administration & dosage
- Middle Aged - administration & dosage
- Mitochondria - metabolism
- Oxygen Consumption - administration & dosage
- Phenotype - administration & dosage
- Stromal Cells - metabolism
- Find related publications in this database (Keywords)
- lipedema
- adipose tissue
- lipidomics
- mitochondrial respiration