Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Smolle, J; Hofmann-Wellenhof, R; Woltsche-Kahr, I; Haas, J; Kerl, H.
Quantitative assessment of fat cells in subcutaneous metastatic melanoma. Correlation with outcome.
Am J Dermatopathol. 1995; 17(6):555-559
Doi: 10.1097/00000372-199512000-00005
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- Führende Autor*innen der Med Uni Graz
- Smolle Josef
- Co-Autor*innen der Med Uni Graz
- Haas Josef
- Hofmann-Wellenhof Rainer
- Kerl Helmut
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- Abstract:
- The metastatic behavior of tumor cells largely depends on tumor-stroma interactions. In the present study, a particular morphological feature of tumor-stroma interaction was evaluated; hematoxylin-eosin-stained slides of 81 lesions of melanoma metastatic to the skin involving the subcutis were examined by automated image analysis for the presence of preexistent fat cells in the tumor. The area occupied by fat cells, expressed in micrometers squared per slide, was of prognostic significance; lesions with a fat cell area of < 41,000 microns 2 showed a 2-year survival rate of 42%, versus 10% in lesions with a fat cell area of > 41,000 microns 2 (log-rank test, z = 3.24; p < or = 0.01). The adverse effect of fat cell area on prognosis still was seen when age, sex, and site of metastatic spread were concomitantly taken into account in a Cox proportional-hazard model. These data indicate that melanoma deposits involving the subcutis with preservation of preexistent subcutaneous fat cells have high metastatic potential and a high risk for rapid internal dissemination.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - pathology
- Age Factors - pathology
- Coloring Agents - diagnostic use
- Eosine Yellowish-(YS) - diagnostic use
- Female - diagnostic use
- Fluorescent Dyes - diagnostic use
- Follow-Up Studies - diagnostic use
- Hematoxylin - diagnostic use
- Humans - diagnostic use
- Image Processing, Computer-Assisted - diagnostic use
- Logistic Models - diagnostic use
- Male - diagnostic use
- Melanoma - pathology
- Middle Aged - pathology
- Multivariate Analysis - pathology
- Prognosis - pathology
- Proportional Hazards Models - pathology
- Sex Factors - pathology
- Skin Neoplasms - pathology
- Survival Rate - pathology
- Treatment Outcome - pathology
- Find related publications in this database (Keywords)
- Melanoma
- Metastasis
- Tumor-Stroma Interaction
- Image Analysis
- Fat Cells