Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Li, Z; Cheng, Y; Fu, K; Lin, Q; Zhao, T; Tang, W; Xi, L; Sheng, L; Zhang, H; Sun, Y.
Circ-PTPDC1 promotes the Progression of Gastric Cancer through Sponging Mir-139-3p by Regulating ELK1 and Functions as a Prognostic Biomarker.
Int J Biol Sci. 2021; 17(15): 4285-4304.
Doi: 10.7150/ijbs.62732
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Zhao Tianyu
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- Abstract:
- Circular RNAs (circRNAs) is a novel class of non-coding RNAs resulting from the non-canonical splicing of linear pre-mRNAs. However, the role of circRNAs in gastric cancer (GC) remains indistinct. This study aims to explore their potential modulation in GC and its prognostic value. We first screen for circRNA expression patterns in GC through GC and adjacent noncancerous tissues by microarray. Based on the bioinformatics analysis of the microarray data, we screened out a novel circRNA, circ-PTPDC1. Then we demonstrated that circ-PTPDC1 was up-regulated in GC cells, tissues, and serum. Its overexpression was positively correlated with age, invasion depth, advanced clinical stages, and worse survival in patients with GC. We further revealed that circ-PTPDC1 promotes the proliferation, migration, and invasion of GC cell lines via sponging miR-139-3p by regulating ELK1. Importantly, we identified that circ-PTPDC1 promotes tumor upgrowth and metabasis in vivo. Additionally, we established its prognostic prediction model based on the follow-up data of the patients. Our study revealed a novel regulatory mechanism and a comprehensive landscape of circ-PTPDC1 in GC, suggesting that circ-PTPDC1 has the potential to be a biomarker for early detection and prognostic prediction of GC.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Biomarkers, Tumor - metabolism
- Cell Line, Tumor - administration & dosage
- Cell Movement - administration & dosage
- Cell Proliferation - administration & dosage
- Female - administration & dosage
- Gene Expression Regulation, Neoplastic - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Mice - administration & dosage
- Mice, Nude - administration & dosage
- MicroRNAs - genetics, metabolism
- Middle Aged - administration & dosage
- Neoplasms, Experimental - metabolism
- Protein Binding - administration & dosage
- Stomach Neoplasms - metabolism, pathology
- Up-Regulation - administration & dosage
- ets-Domain Protein Elk-1 - genetics, metabolism