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SHR Neuro Cancer Cardio Lipid Metab Microb

Yang, BY; Guo, Y; Bloom, MS; Xiao, X; Qian, ZM; Liu, E; Howard, SW; Zhao, T; Wang, SQ; Li, S; Chen, DH; Ma, H; Yim, SH; Liu, KK; Zeng, XW; Hu, LW; Liu, RQ; Feng, D; Yang, M; Xu, SL; Dong, GH.
Ambient PM₁ air pollution, blood pressure, and hypertension: Insights from the 33 Communities Chinese Health Study.
Environ Res. 2019; 170: 252-259. Doi: 10.1016/j.envres.2018.12.047
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Co-authors Med Uni Graz: Zhao Tianyu
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Abstract:: No evidence exists concerning the association between blood pressure and ambient particles with aerodynamic diameter ≤ 1.0 µm (PM₁), a major component of PM_2.5 (≤ 2.5 µm) particles, and potentially causing more hazardous health effects than PM_2.5. We aimed to examine the associations of blood pressure in adults with both PM₁ and PM_2.5 in China. In 2009, we randomly selected 24,845 participants aged 18-74 years from 33 communities in China. Using a standardized mercuric-column sphygmomanometer, we measured blood pressure. Long-term exposure (2006-08) to PM₁ and PM_2.5 were estimated using a spatial statistical model. Generalized linear mixed models were used to evaluate the associations between air pollutants and blood pressure and hypertension prevalence, controlling for multiple covariates. A 10-μg/m³ increase in PM₁ was significantly associated with an increase of 0.57 (95% CI 0.31-0.83) mmHg in systolic blood pressure (SBP), 0.19 (95% CI 0.03-0.35) mmHg increase in diastolic blood pressure (DBP), and a 5% (OR=1.05; 95% CI 1.01-1.10) increase in odds for hypertension. Similar associations were detected for PM_2.5. Furthermore, PM_1-2.5 showed no association with blood pressure or hypertension. In summary, both PM₁ and PM_2.5 exposures were associated with elevated blood pressure levels and hypertension prevalence in Chinese adults. In addition, most of the pro-hypertensive effects of PM_2.5 may come from PM₁. Further longitudinal designed studies are warranted to validate our findings.
Find related publications in this database (using NLM MeSH Indexing): Adolescent - administration & dosage; Adult - administration & dosage; Aged - administration & dosage; Air Pollutants - administration & dosage; Air Pollution - statistics & numerical data; Asian People - administration & dosage; Blood Pressure - administration & dosage; China - epidemiology; Environmental Exposure - administration & dosage; Humans - administration & dosage; Hypertension - epidemiology; Middle Aged - administration & dosage; Particulate Matter - administration & dosage; Residence Characteristics - administration & dosage; Young Adult - administration & dosage