Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eckert, M; Gerken, M; Werner, JM; Blaj, S; Füsi, F; Bogovic, N; Schlitt, HJ; Hornung, M; Piso, P; Acs, M.
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for children and young adults: experience from two high volume centers
PLEURA PERITONEUM. 2025;
Doi: 10.1515/pp-2025-0011
Web of Science
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- Co-Autor*innen der Med Uni Graz
- Füsi Ferdinand
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- Abstract:
- Objectives peritoneal surface malignancy in children is rare with a dismal prognosis. This bicentric study evaluated CRS with HIPEC in patients aged 2-25 years.Methods Clinicopathological and treatment-related factors were retrospectively analyzed from 21 patients undergoing CRS and HIPEC between 2009 and 2022. Endpoints were feasibility, chemotherapeutic compound, complications, and overall survival (OS).Results The mean age was 20.4 years. The mean peritoneal cancer index (PCI) was 12.8. Mean follow-up period was 6.8 years. Median overall survival time was 2.4. 5-year survival rate was 42.9 %. 76.2 % had primary and 23.8 % recurrent disease. The most common primary tumor locations were colon (33.3 %) and appendix (14.3 %). Adenocarcinoma was the most common histological subtype (71.4 %). Univariable Cox regression analysis showed significant impaired OS after previous chemotherapy (p=0.46) and incomplete cytoreduction CCR-2 (p=0.43). No perioperative mortalities occurred. The incidence of major complications was 24 %.Conclusions Multimodal treatment can be considered in pediatric patients with peritoneal carcinomatosis. It presents a safe and feasible therapy with manageable complications and no perioperative mortality when performed by an experienced multidisciplinary team. Indication for CRS and HIPEC in children should be an individual decision by an interdisciplinary tumor board in the absence of better alternatives.
- Find related publications in this database (Keywords)
- cytoreductive surgery
- hyperthermic intraperitoneal chemotherapy
- peritoneal neoplasm
- pediatric neoplasm
- survival analysis
- multimodal therapy