Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

Ratzenhofer-Komenda, B; Kovac, H; Smolle-Jüttner, FM; Friehs, GB; Schwarz, G.
Quantification of the dermal vascular response to hyperbaric oxygen with laser-Doppler flowmetry.
Undersea Hyperb Med. 1998; 25(4):223-227
Web of Science PubMed Google Scholar

Leading authors Med Uni Graz: Ratzenhofer-Komenda Beatrice
Co-authors Med Uni Graz: Schwarz Gerhard; Smolle-Juettner Freyja-Maria
Altmetrics:
Dimensions Citations:
Plum Analytics:
Abstract:: The vasoconstrictive response to hyperbaric oxygen (HBO2) therapy was non-invasively quantified in eight healthy volunteers at 1.95 and 2.5 atm abs (197.5 and 253.2 kPa; multiplace chamber, air environment) by laser-Doppler flowmetry (LDF). The sensors for continuous measurement of microvascular perfusion (flux) and skin temperature were localized on the thenar eminence. Transcutaneous oxygen (tcPO2) and carbon dioxide (tcPCO2) tensions, blood pressure, heart rate, respiration rate, peripheral oxygen saturation, and temperature of the hyperbaric chamber were recorded at five conditions: 1) baseline--air breathing at 1.0 atm abs, 2) after 15 min of HBO2 at 2.5 atm abs, 3) after 15 min of HBO2 at 1.95 atm abs, 4) 1 min after decompression with oxygen breathing at 1.0 atm abs, and 5) after 15 min of breathing air at 1.0 atm abs. Flux decreased continuously at conditions 2 (76.5%), 3 (50.6%), and 4 (37% of baseline, P < 0.05; Tukey test). Skin temperature fell below baseline at conditions 2, 3, 4 (P < 0.01, Tukey test), and 5 (P < 0.05, Tukey test, P < 0.001, analysis of variance). Range of correlation between inspired gas PO2 (PIO2) and alteration of flux 0.91 to 0.72, median -0.41. Correlation between PIO2 and tcPO2, r = 0.98. Chamber temperature and tcPCO2 remained stable. HBO2 reduced dermal microcirculation and temperature disproportionate to PIO2. LDF is suitable for use under hyperbaric conditions.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Analysis of Variance -; Blood Gas Monitoring, Transcutaneous -; Female -; Hemodynamic Processes -; Humans -; Hyperbaric Oxygenation -; Laser-Doppler Flowmetry -; Male -; Microcirculation -; Middle Aged -; Skin - blood supply; Vasoconstriction - blood supply
Find related publications in this database (Keywords): Hyperbaric Oxygenation; Laser-Doppler Flowmetry; Microcirculation; Monitoring; Dermal Blood Flow; Microvascular Perfusion