Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
van, de, Velden, D; Heide, EC; Bouter, C; Bucerius, J; Riedel, CH; Focke, NK.
Effects of inverse methods and spike phases on interictal high-density EEG source reconstruction.
Clin Neurophysiol. 2023; 156: 4-13.
Doi: 10.1016/j.clinph.2023.08.020
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Bucerius Jan Alexander
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- Abstract:
- OBJECTIVE: To determine the effect of inverse methods and timepoints of interictal epileptic discharges (IEDs) used for high-density electric source imaging (hd-ESI) in pharmacoresistant focal epilepsies. METHODS: We retrospectively evaluated the hd-ESI and [18F]fluorodeoxyglucose positron emission tomography (18FDG-PET) of 21 operated patients with pharmacoresistant focal epilepsy (Engel I). Volumetric hd-ESI was performed with three different inverse methods such as the inverse solution linearly constrained minimum variance (LCMV, a beamformer method), standardized low resolution electromagnetic tomography (sLORETA) and weighted minimum-norm estimation (wMNE) and at different IED phases. Hd-ESI accuracy was determined by volumetric overlap and distance between hd-ESI source maximum, as well as 18FDG-PET hypometabolic region relative to the resection zone (RZ). RESULTS: In our cohort, the shortest distances and greatest volumetric overlaps to the RZ were found in the half-rise and peak-phase for all inverse methods. The distance to the RZ was not different between the centroid of the clinical hypothesis-based cluster and the source maximum in peak-phase. However, the distance of the hypothesis-based cluster was significantly shorter compared to the cluster selected by the smallest p-value. CONCLUSIONS: Hd-ESI provides the greatest accuracy in determining the RZ at the IED half-rise and peak-phase for all applied inverse methods, whereby sLORETA and LCMV were equally accurate. SIGNIFICANCE: Our results offer guidance in selecting inverse methods and IED phases for hd-ESI, compare the performance of hd-ESI and 18FDG-PET and encourage future studies in investigating the relationship between interictal ESI and 18FDG-PET hypometabolism.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Electroencephalography - methods
- Magnetic Resonance Imaging - methods
- Retrospective Studies - administration & dosage
- Fluorodeoxyglucose F18 - administration & dosage
- Epilepsy - surgery
- Epilepsies, Partial - administration & dosage
- Find related publications in this database (Keywords)
- EEG
- Interictal electrical source imaging
- (18)FDG-PET hypometabolism
- Inverse methods
- Focal epilepsy