Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmaljohann, J; Gündisch, D; Minnerop, M; Joe, A; Bucerius, J; Dittmar, C; Jessen, F; Guhlke, S; Wüllner, U.
A simple and fast method for the preparation of n.c.a. 2-[18F]F-A85380 for human use
APPL RADIAT ISOTOPES. 2005; 63(4): 433-435.
Doi: 10.1016/j.apradiso.2005.05.040
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Bucerius Jan Alexander
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- Abstract:
- 2-[F-18]F-A85380 is the first subtype selective PET-radiotracer to visualize the distribution of alpha(4)beta(2) nicotinic acetylcholine receptors in human brain in vivo. We investigated a fast and safe automated production of 2-[F-18]F-A85380 by purification of the BOC-protected intermediate product with a combination of solid phase extraction cartridges. After deprotection, adjustment of the pH and sterile filtration n.c.a. 2-[F-18]F-A85380 was applicable for the use in human studies with a high specific activity and an overall radiochemical yield of 55% in 35 minutes. (c) 2005 Elsevier Ltd. All rights reserved.
- Find related publications in this database (Keywords)
- nicotinic acetylcholine receptor
- fluor-18
- 2-F-18-A85380
- PET