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Ezziddin, JBS; Brockmann, H; Palmedo, H; Biersack, HJ.
Impact of thyroid metabolism on the course of INR levels in a patient with systemic anticoagulation suffering from amiodarone-induced thyrotoxicosis
EXP CLIN ENDOCR DIAB. 2007; 115(9): 606-609. Doi: 10.1055/s-2007-984439
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Führende Autor*innen der Med Uni Graz
Bucerius Jan Alexander
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Abstract:
We report the case of a 60 year old female patient on continuous systemic anticoagulation therapy with coumarin due to mechanical aortic valve replacement and a more than 3 years lasting amiodarone therapy due to severe ventricular extrasystoles suffering from amiodarone induced thyrotoxicosis (AIT). During the course of AIT, showing different thyroid metabolic conditions, INR levels revealed a course closely related to the thyroid conditions indicating a significant and clear-cut effect of both hyper- and hypothyroidism on systemic anticoagulation therapy with coumarin. This continuous interaction of different thyroid metabolic conditions and the anticoagulation state could be well documented in the presented case over a time period of approximately five months.

Find related publications in this database (Keywords)
systemic anticoagulation
thyroid metabolism
amiodarone-inducedthyrotoxicosis
INR
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