Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Direkt zur Navigaton springen.
Direkt zum Inhalt springen.

Navigation/Suche

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Schmaljohann, J; Guendisch, D; Minnerop, M; Bucerius, J; Joe, A; Reinhardt, M; Guhlke, S; Biersack, HJ; Wuellner, U.
In vitro evaluation of nicotinic acetylcholine receptors with 2-[¹⁸F]F-A85380 in Parkinson's disease
NUCL MED BIOL. 2006; 33(3): 305-309. Doi: 10.1016/j.nucmedbio.2005.12.012
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Bucerius Jan Alexander
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Nicotinic acetylcholine receptors (nAChR) are involved in many physiological functions and appear to be affected in neurodegenerative diseases like Alzheimer's disease and Parkinson's disease (PD). Here, we describe the in vitro evaluation of nAChRs in PD with 2-[F-18]F-A85380, a ligand with high affinity to the beta 2 nAChR subunit. Autoradiography with 2-[F-18]F-A85380 ill untreated rat brain corresponded to the known distribution of alpha 4 beta 2 nAChRs with high uptake in the thalamus, moderate uptake in the striatum and cortex and low uptake in the cerebellum (47%, 43% and 19% of the thalamus, respectively). The localization of alpha 4 beta 2 nAChRs in the striatum was investigated in rodents with unilateral lesion of the substantia nigra. 2-[F-18]F-A85380 binding was significantly reduced in the striatum ipsilateral to the lesion side (to 64% of the contralateral side), indicating that a fraction of alpha 4 beta 2 nAChRs is located on dopaminergic terminals, whereas another fraction resides on striatal interneurons or cortical afferents. Similarly, in human brain sections of PD patients, 2-[F-18]F-A85380 uptake was significantly reduced not only ill the caudate and putamen but also in the thalamus (approximately 30% of the binding of control brain in all three regions); within the striatum, nAChRs in the putamen were significantly more severely affected as in the caudate. The observed pattern of alpha 4 beta 2* nAChR loss demonstrates the potential of 2-[F-18]F-A85380 for further investigations of this positron emission tomography ligand for in vivo studies of alpha 4 beta 2* nAChRs ill PD. (c) 2006 Elsevier Inc. All rights reserved.
Find related publications in this database (Keywords): nicotinic acetylcholine receptor; fluorine-18; 2-F-18-A85380; Parkinson's disease; PET