Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bucerius, J; Herkel, C; Joel, AY; Altehoefer, C; Finke, J; Moser, E; Reinhardt, MJ.
18F-FDG PET and conventional imaging for assessment of Hodgkin's disease and non Hodgkin's lymphoma -: An analysis of 193 patient studies
NUKLEARMED-NUCL MED. 2006; 45(3): 105-110.
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Bucerius Jan Alexander
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- Abstract:
- The aim of this study was to assess the diagnostic value of FDG-PET and conventional imaging (CI) in a large series of patient with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL) at three time points during their course of disease. Patients, methods: 169 consecutive lymphoma patients (69 HD; 100 NHL) were induced. 193 FDG-PET studies were performed for staging at baseline in 42 cases, for post-therapeutic monitoring in 103, and for diagnosis of recurrence in 48 cases. Performance indices of sensitivity, specificity, positive (PPV) and negative predictive value (NPV), and accuracy of metabolic FDG-PET and morphological CI were calculated. Differences in staging and diagnosis of residual or recurrent lymphoma were compared. Results: FDG-PET changed staging in 36% of cases for staging at baseline, in 52% of cases for monitoring response to treatment, and in 29% for diagnosis of recurrence. FDG-PET staging results were confirmed in 80% for staging at baseline, in 74% for monitoring response to treatment, and in 50% for diagnosis of recurrence. FDG-PET and CI differed significantly at monitoring response to treatment for sensitivity (0.91 versus 0.69; p < 0.02), specificity (0.90 versus 0.38; p < 0,00001), PPV (0.77 versus 0.42; p < 0.001), and accuracy (0.83 versus 0.55; p < 0.02). Conclusion: FDG-PET should be considered as the diagnostic modality of choice for post-therapeutic assessment of lymphomo patients and may be a reliable alternative to CI for staging at baseline and diagnosis of recurrence.
- Find related publications in this database (Keywords)
- Hodgkin's disease
- non-Hodgkin's lymphoma
- positron emission tomography
- computed tomography
- magnetic resonance imaging