Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Bucerius, J; Joe, AY; Herder, E; Brockmann, H; Biermann, K; Palmedo, H; Tiemann, K; Biersack, HJ.
Pathological ^99mTc-sestamibi myocardial perfusion scintigraphy is independently associated with emerging cardiac events in elderly patients with known or suspected coronary artery disease
ACTA RADIOL. 2011; 52(1): 52-58. Doi: 10.1258/ar.2010.090482
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Bucerius Jan Alexander
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Abstract:: Background: Only few data are available regarding the prognostic impact of myocardial perfusion scintigraphy with Tc-99m-sestamibi (MPS) regarding emerging cardiac events in elderly patients Purpose: To evaluate the prognostic value of MPS regarding emerging cardiac events in patients aged >= 70 years with known or suspected coronary artery disease (CAD). Material and Methods: One hundred and thirty-three patients (74.6 +/- 3.7 years) who underwent exercise or pharmacological stress/rest MPS were included in this analysis. Semi-quantitative visual interpretation of MPS images was performed and Summed-Stress- (SSS), Summed-Difference- (SDS), and Summed-Rest Scores (SRS) were calculated. Multivariate logistic regression analyses were calculated for evaluation of the independent prognostic impact of MPS results and several cardiac-related patient characteristics with regard to emerging cardiac events. Kaplan-Meier survival- and log rank analyses were calculated for assessment of cardiac event-free survival. Results: Pathological SSS (OR: 3.3), angina (OR: 2.7) and ischemic ECG (OR: 3.0) were independently associated with cardiac events. Patients with pathological SSS (p = 0.005) and ischemic ECG (p = 0.012) had a significantly lower incidence of cardiac event-free survival. Conclusion: Pathological MPS is independently associated with emerging cardiac events predicting a significantly lower incidence of cardiac event-free survival in patients aged >= 70 years.
Find related publications in this database (Keywords): Coronary artery disease; elderly; myocardial perfusion scintigraphy; Tc-99m-sestamibi; prognostic value