Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bucerius, J; Joe, AY; Herder, E; Brockmann, H; Reinhardt, MJ; Palmedo, H; Tiemann, K; Biersack, HJ.
Significant Association of Female Gender with Lower Degree of Pathological 99mTc-sestamibi Scintigraphy Results as well as Higher Cardiac-Related Deaths Free Survival in Elderly Patients
MED KLIN. 2010; 105(12): 901-909.
Doi: 10.1007/s00063-010-1155-y
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Bucerius Jan Alexander
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- Abstract:
- The aim of the present study was to assess the impact of female gender on the extent of myocardial perfusion defects as revealed by (99m)Tcsestamibi myocardial perfusion scintigraphy (MPS) and on emerging cardiac events (CE) in patients aged a parts per thousand yen 70 years. 86 patients aged a parts per thousand yen 70 years with known or suspected CAD undergoing MPS (74.4 +/- 3.2 years; women: n = 46; 53.5%) were included in this study. Semiquantitative analysis of MPS was performed and summed stress (SSS), summed difference (SDS), and summed rest scores (SRS) were calculated. Emerging CE comprised myocardial revascularization and -infarction and cardiac-related death. Multivariate regression analysis was performed to assess the independent prognostic impact of several patient related variables on MPS results. Kaplan-Meier- and log rank analyses were calculated for assessment of CE free survival as related to gender. Normal SSS (87.0% vs. 27.5%; p < 0.0001), SDS (80.4% vs. 27.5%; p < 0.0001), and SRS (97.8% vs. 82.5%; p = 0.023) were significantly more often found in women, whereas incidence of mildly and severely impaired SSS (6.5% vs. 35%; p = 0.001 and 2.2% vs. 25%; p = 0.002, respectively) and SDS (15.2% vs. 52.5%; p < 0.0001 and 2.2% vs. 17.5%; p = 0.023, respectively) were significantly higher in men. Multivariate logistic regression analysis revealed female gender as an independent predictor of normal SSS (odds ratio/OR: 17.6) and SDS (OR: 53.3). Female gender was associated with a significant higher cardiac-death free survival compared to male patients (p = 0.031). Female gender is independently associated with a significantly lower degree of pathological MPS results and a higher cardiac-death free survival in elderly patients.
- Find related publications in this database (Keywords)
- Coronary artery disease
- Female gender
- Elderly
- Tc-99m-sestamibi myocardial perfusion scintigraphy
- Cardiac related outcome