Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Manka-Waluch, A; Palmedo, H; Reinhardt, MJ; Joe, AY; Manka, C; Guhlke, S; Biersack, HJ; Bucerius, J.
Myocardial uptake characteristics of three 99mTc-labeled tracers for myocardial perfusion imaging one hour after rest injection
ANN NUCL MED. 2006; 20(10): 663-670.
Doi: 10.1007/BF02984677
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Bucerius Jan Alexander
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- Abstract:
- Objective: Tc-99m-tetrofosmin and Tc-99m-sestamibi are approved tracers for myocardial perfusion studies. Recently, a Tc-99m-MIBI preparation from a different manufacturer (Tc-99m-cardiospect-MIBI) has been introduced to the market. Therefore, the aim of this study was the evaluation of Tc-99m-tetrofosmin as well as of two different Tc-99m-labeled MIBI tracers with regard to differences in imaging quality under resting conditions. Methods: Sixty patients (mean age 63.8 years +/- 1.25) with known or suspected coronary artery disease but without evidence of rest-ischemia were included. Twenty patients in each group were examined by a two-day-rest-stress protocol using the three Tc-99m-labeled tracers. Visual analysis of all images was performed by two experienced physicians blinded with regard to the applied tracer. Regions of interest (ROI) were defined over the heart, lung and whole body only in the rest imaging in order to calculate heart-to-lung, lung-to-whole body-, and heart-to-whole body-ratios. Results: The heart-to-lung ratio was statistically significant higher for Tc-99m-cardiospect-MIBI as compared to Tc-99m-sestamibi as well as to Tc-99m-tetrofosmin. Furthermore, a significantly higher heart-to-lung ratio was found for Tc-99m-sestamibi as compared to Tc-99m-tetrofosmin. The heart-to-whole body-ratio and the lung-to-whole body-ratio were equivalent between all tracers. Visual analysis revealed only slight differences regarding image quality between all tracers. Conclusions: ROI analysis surprisingly revealed a significant higher myocardial uptake and consequently a higher heart-to-lung ratio for Tc-99m-cardiospect-MIBI. Whether this leads to a better visual image quality has to be evaluated in future studies with larger study populations as well as serniquantitative segmental analysis of the myocardial perfusion images.
- Find related publications in this database (Keywords)
- Tc-99m-sestamibi
- Tc-99m-tetrofosmin
- Tc-99m-cardiospect-MIBI
- myocardial uptake
- pulmonary uptake